Research in flies points to enhanced fatty acid metabolism in muscle as a key driver of the lifespan extending process
Fruit flies on restriction (DR) need to be physically active in order to get the lifespan extending benefits that come from their Spartan diet.
If the same axiom holds true in humans, those practicing caloric restriction in hopes of living longer need to make sure they eat enough to avoid fatigue.
According to research at the Buck Institute, flies on DR shift their metabolism toward increasing fatty acid synthesis and breakdown, specifically in muscle tissue.
“Dietary restriction is known to enhance spontaneous movement in a variety of species including primates, however this is the first examination of whether enhanced physical activity is necessary for its beneficial effects,” said Buck faculty Pankaj Kapahi, PhD, who runs the lab where the research took place.
“This study establishes a link between DR-mediated metabolic activity in muscle, increased movement and the benefits derived from restricting nutrients,” he said, adding that flies on DR who could not move or had inhibited fat metabolism in their muscle did not exhibit an extended lifespan.
“Our work argues that simply restricting nutrients without physical activity may not be beneficial in humans,” said Kapahi.
The research was published in the July 3, 2012 edition of Cell Metabolism.
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